Published in Gene Therapy Weekly, October 7th, 1996
Cultured human keratinocytes generate cohesive sheets of epithelium. These epithelial sheets are routinely used to make autologous grafts for patients suffering from large skin and mucosal defects. The engraftment of stem cells in these sheets assure the persistence and regeneration of the epidermis during the patients lifetime.
It has been shown that these epidermal keratinocytes can synthesize and secrete gene products that can accomplish autocrine, paracrine, and even endocrine functions. These polypeptides are capable of crossing the...
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