Cancer Vaccines
Transloading Tumor Cells with a Foreign Peptide Generates A Potent Immune Response
Published in Gene Therapy Weekly, October 21st, 1996
The active immunotherapy of cancer is often blocked by the poor immunogenicity of cancer cells due to their 'self' origin. Studies in animal models have shown, however, that antitumor immunity can be overcome when expression of a foreign gene product is elicited in the tumor vaccine. Methods have included viral infection (W. Liebrich et al., Eur. J. Cancer, 1991;27:703-10) or transfection of a viral gene (E.R. Fearon et al., Cancer Res. 1988;48:2975-80).
Tumor cells...
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Source: Gene Therapy Weekly (1996-10-21)
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