Parkinson's Disease

Genetic Defect Linked to Disease

Published in Gene Therapy Weekly, November 4th, 1996

Parkinson's disease patients may indeed have a genetic mutation that increases susceptibility to the shaking disorder, despite the fact that the sporadic nature of the disease does not follow the population patterns of most genetic diseases.

According to a report published in a recent issue of the Annals of Neurology, Parkinson's disease patients have a defect in the DNA carried in their mitochondria - the cellular "powerhouses" that produce all the energy used by a cell (Annals of Neurology 1996;40:18-26). Mitochondria are bacteria-sized structures that contain DNA separate from the 46 chromosomes found in the nucleus of the cell. The mitochondrial DNA is inherited...

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Source: Gene Therapy Weekly (1996-11-04)

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