Renal Disease
"A Gene Transfer System Establishes Interleukin-6 Neither Promotes Nor Suppresses Renal Injury."
Published in Gene Therapy Weekly, November 4th, 1996
According to the authors' abstract of an article published in American Journal of Physiology - Renal Fluid and Electrolyte Physiology, "Conflicting reports claim that circulating interleukin (IL)-6 promotes or suppresses renal disease. Although autoimmune MRL-lpr mice have an increase in serum IL-6, and kidneys can produce IL-6, the relevance of systemic and local exposure remains undefined. To investigate the impact of IL-6 on kidney disease, we constructed a gene transfer approach to deliver sustained, stable IL-6 into the kidney and circulation. We infused syngeneic genetically modified tubular epithelial cells (IL-6-TEC) under the renal capsule of autoimmune and nonautoimmune mice. ...
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Source: Gene Therapy Weekly (1996-11-04)
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