DNA Vaccines

Suppressive Vaccination Shows Promise Against Autoimmune Diseases

Published in Gene Therapy Weekly, November 11th, 1996

Reversal of the autoimmune response from Th1 to Th2 may make DNA immunization for Th-1 mediated autoimmune diseases a novel therapeutic approach.

The goal of most vaccination protocols is to boost the immune system's response. Autoimmune diseases, however, are a result of an overzealous immune response against the body's own tissues. Recent research investigated the concept of 'suppressive' vaccination as a new therapy for autoimmune diseases.

Using an experimental murine autoimmune encephalomyelitis (EAE) model, a T cell-mediated autoimmunity which shares many features with multiple sclerosis, researchers Ari Waisman et al. discovered a novel...

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Source: Gene Therapy Weekly (1996-11-11)

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