Chemosensitization
Parvovirus Mediates Improved Sensitization of Chemotherapeutics
Published in Gene Therapy Weekly, November 18th, 1996
Chemotherapy of human cancers often is limited by the increasing resistance of tumor cells in the dose range which can be tolerated by patients. The challenge of cancer therapy has lead researchers to devise new ways of protecting the patient against cytotoxic effects, to develop new therapies, and to sensitize specifically the cancer cells to the cytotoxic effects of current chemotherapeutics.
Recent research has shown that non-pathogenic human adeno-associated viruses (AAV) can sensitize HeLa cervical cancer cells to subsequent gamma irradiation both in vitro and in...
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Source: Gene Therapy Weekly (1996-11-18)
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