Cystic Fibrosis

Technique Stimulates Cells To Repair Their Own Genetic Defects

Published in Gene Therapy Weekly, November 18th, 1996

Researchers at the University of California at San Francisco (UCSF) have restored affected cells' ability to function by providing living cells with material needed to correct a mistake in DNA that causes cystic fibrosis (CF).

The technique might one day be used to treat genetic diseases that afflict millions worldwide, according to Dieter Gruenert, Ph.D., UCSF. Gruenert and colleagues described their approach for correcting genetic defects in the October 1996 issue of Gene Therapy.

The UCSF laboratory team invented the technique, called "small fragment homologous replacement," to stimulate the repair of cultured lung cells harboring the most common...

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Source: Gene Therapy Weekly (1996-11-18)

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