"Fusigenic Viral Liposome for Gene Therapy in Cardiovascular Diseases."

According to the authors' abstract of an article published in Proceedings of the National Academy of Sciences of the United States of America, "To improve the efficiency of liposome-mediated DNA transfer as a tool for gene therapy, we have developed a fusigenic liposome vector based on principles of viral cell fusion. The fusion proteins of hemagglutinating virus of Japan (HVJ; also Sendai virus) are complexed with liposomes that encapsulate oligodeoxynucleotide or plasmid DNA. Subsequent fusion of HVJ-liposomes with plasma membranes introduces the DNA directly into the cytoplasm. In addition, a DNA-binding nuclear protein is incorporated into the HVJ-liposome particle to enhance...

Want to see the full article?

• Purchase this article for only $3.00