Vectors (Non-Viral)
Non-Cationic Liposomes and Histone H1 Complexes Mediate Efficient Transfection
Published in Gene Therapy Weekly, November 25th, 1996
Liposomes are attractive vectors for gene delivery for several reasons, including low toxicity levels, ease of use, and high fusogenic potential. Several studies have used neutral or anionic liposomes to deliver DNA to cells, and from a structural standpoint, it generally has been thought that the DNA must be carried inside the aqueous interior of the liposome to be transfectable. Unfortunately, complete encapsulation of DNA within the liposomes, although possible, is limited by low entrapment...
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Source: Gene Therapy Weekly (1996-11-25)
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