Vectors (Non-Viral)
Receptor-Mediated Gene Transfer Via (alpha)2 -Macroglobulin/Poly(L)-Lysine
Published in Gene Therapy Weekly, November 25th, 1996
The (alpha)2 -macroglobulin receptor/low density lipoprotein receptor-related protein ((alpha)2 -MR/LRP) is unique in its ability to bind and endocytose a variety of very different ligands. These include lipoprotein remnants, cytokines/growth factors, and proteases (in complex with (alpha)2 -macrogobulin), as well as plasminogen activators complexed with inhibitors. (alpha)2 -MR/LRP is a very large cell surface receptor (mol. wt 600 kDa) that is capable of internalizing its ligands...
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Source: Gene Therapy Weekly (1996-11-25)
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