"Expression of p53 in Saos-2 Osteosarcoma Cells Induces Apoptosis Which Can Be Inhibited by Bcl-2 or the Adenovirus E1B-55 kDa Protein."

According to the authors' abstract of an article published in Cell Growth & Differentiation, "Studies were carried out to determine the effects of introducing p53 using an adenovirus gene transfer vector into p53 null human Saos-2 osteogenic carcinoma cells. Expression of p53 led to cell death within 30-40 h. The morphology of these cells as determined by electron microscopy indicated that death was by apoptosis. Such death was significantly reduced in Saos-2 variants that express high levels of the Bcl-2 suppressor of apoptosis. It was also found that the E1B-55 kDa protein of human adenovirus type 5, which was known to bind and inactivate p53, blocks Saos-2 cell death following...

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