Melanoma
"Active Specific Immunotherapy of Pulmonary Metastasis with Vaccinia Melanoma Oncolysate Prepared from Granulocyte/Macrophage Colony-Stimulating-Factor-Gene-Encoded Vaccinia Virus."
Published in Gene Therapy Weekly, January 27th, 1997
According to the authors' abstract of an article published in Journal of Cancer Research and Clinical Oncology, "Vaccinia melanoma oncolysate (VMO) prepared with recombinant vaccinia virus encoding the gene of murine granulocyte/macrophage-colony-stimulating factor (GM-CSF) was tested for its therapeutic effect on melanoma pulmonary metastasis. The murine pulmonary metastasis model was established by injecting 2x105 B16F10 melanoma cells into the tail vein of a C57BL/6 mouse. Intraperitoneal injection of VMO was performed in tumor-bearing mice 3 and 10 days after B16F10 cell inoculation. The results showed that treatment with VMO prepared with GM-CSF-gene-encoded vaccinia...
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Source: Gene Therapy Weekly (1997-01-27)
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