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Vector Development

Hybrid Vector Is a Simple and Effective Gene Transfer Vehicle

Published in Gene Therapy Weekly, February 17th, 1997

A hybrid herpesvirus miniviral vector (pH300) is an effective and simple gene transfer system in vitro and in vivo.

Suming Wang and Jean-Michel Vos from the University of North Carolina have developed an infectious miniviral vector based on Epstein-Barr virus (EBV) and herpes simplex virus type 1 (HSV-1) which shows potential for use as a cancer and inherited gene therapy vector ("A Hybrid Herpesvirus Infectious Vector Based on Epstein-Barr Virus and Herpes Simplex Virus Type 1 for Gene Transfer into Human Cells In Vitro and In Vivo," Journal of Virology, December 1996;70(12):8422-30).

"In this study, we present a novel EBV/HSV-based miniviral...

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