Published in Gene Therapy Weekly, February 17th, 1997
De-Min Zhou and Japanese colleagues explored the mechanism of inhibition and reported their results at the 6th Antisense Symposium, Japan, held December 2-4, 1996, in Tsukuba, Japan.
"The hammerhead is a small RNA motif that can cause magnesium-dependent cleavage of an RNA chain at a unique site," stated Zhou et al. "This reaction has the potential to inactivate RNA molecules in vivo, and the ribozyme may represent a new protocol in gene therapy."
Ribozyme activity depends on divalent metal ions, noted the...
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