Suicide Gene Therapy
Liver Toxicity Associated with Adv-Mediated HSV-tk/GCV Gene Therapy
Published in Gene Therapy Weekly, February 24th, 1997
Animal models with artificially induced liver tumors of colorectal origin treated locally with either retrovirus or adenovirus vector-mediated HSV-tk/GCV suicide gene therapy have been studied previously. Although extensive testing of retroviral vectors has not revealed any major signs of toxicity (D.W. Moorman, J. Surg. Oncol., 1994;57:152-6), no toxicity studies using adenoviral mediated HSV-tk/GCV gene therapy have been reported to date.
Karsten Brand and colleagues...
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Source: Gene Therapy Weekly (1997-02-24)
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