Cardiology
"Physiological Effects of Adenoviral Gene Transfer of Sarcoplasmic Reticulum Calcium ATPase in Isolated Rat Myocytes."
Published in Gene Therapy Weekly, March 3rd, 1997
According to the authors' abstract of an article published in Circulation, "Background: In myocardial cells, relaxation is governed primarily by the sarcoplasmic reticulum (SR) Ca2+-ATPase transporting enzyme, which regulates Ca2+ sequestration into the SR. Human and experimental cardiomyopathies are associated with reduced SR Ca2+-ATPase activity. Methods and Results: To modify intracellular calcium mobilization, we created a recombinant adenovirus designed to overexpress the cardiac SR Ca2+-ATPase (SERCA2a) under the control of the Rous sarcoma virus (RSV). In neonatal rat myocytes, Ad.RSV.SERCA2a increased the expression of SERCA2a in a concentration-dependent and...
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Source: Gene Therapy Weekly (1997-03-03)
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