"Induction of Antigen-Presenting Capacity in Tumor Cells upon Infection with Non-Replicating Recombinant Vaccinia Virus Encoding Murine MHC Class II and Costimulatory Molecules."

According to the authors' abstract of an article published in Journal of Immunological Methods, "The possibility of inducing antigen-presenting capacity in cells normally lacking such capacity, currently represents a major goal in vaccine research. To address this issue we attempted to generate 'artificial' APC able to stimulate CD4⁺ T-cell responses when tumor cells were infected with a single, recombinant, vaccinia virus (rVV) containing the two genes encoding murine MHC class II I-A(k) and a third gene encoding the murine B7-1 (mB7-1) costimulatory molecule. To minimize the cytopathic effect and to improve safety, in view of possible in vivo applications, we made this rVV...

Want to see the full article?

• Purchase this article for only $3.00