Colon Cancer

Mutated Cell Death Gene Linked with Early Stage Cancer

Published in Gene Therapy Weekly, March 10th, 1997

A study directed by Dr. Manuel Perucho, Burnham Institute, La Jolla, California, has linked the mutation of a gene known to control cell growth with the earliest stage of an inherited form of colon cancer.

The data were published in the February 13, 1997, issue of Science (M. Perucho, et al., "Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype," Science, February 14, 1997).

Certain types of inherited cancer, including colon cancer, are identified with microsatellite mutator syndrome (MMS).

Normally, when DNA is copied, routine mistakes - "typos" - are corrected by DNA repair...

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Source: Gene Therapy Weekly (1997-03-10)

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