Cancer Gene Therapy
"In vivo Gene Therapy for alpha-Fetoprotein-Producing Hepatocellular Carcinoma by Adenovirus-Mediated Transfer of Cytosine Deaminase Gene."
Published in Gene Therapy Weekly, March 17th, 1997
According to the authors' abstract of an article published in Cancer Research, "The Lu-fetoprotein (AFP) gene is normally expressed in fetal liver and is transcriptionally silent in adult liver but overexpressed in human hepatocellular carcinoma (HCC). Here, we demonstrate that replication defective recombinant adenoviral vectors, containing the human AFP promoter/enhancer, can be used to express the Escherichia coli cytosine deaminase (CD) gene (AdAFPCD) and the beta-galactosidase gene (AdAF-PlacZ) in AFP-producing HCC cell lines. Expression of the CD gene by adenovirus from the AFP promoter/enhancer (AdAFPCD) induced cells sensitive to 5-fluorocytosine (5FC) in the AFP-producing...
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Source: Gene Therapy Weekly (1997-03-17)
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