Published in Gene Therapy Weekly, March 17th, 1997
Up to this point, many of the currently used vector systems for infecting primary human cells have revolved around onco-retroviruses such as Moloney murine leukemia virus (Mo-MLV). These viruses, however, are dependent on cell division for efficient integration into the host cell genome. Lentiviruses, including HIV-1, do not necessarily need cell division for completion of their replicative cycle. As such, these viruses can infect quiescent primary human cells.
Jakob Reiser and colleagues from the National Institutes...
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