"Intrapericardial Administration of Adenovirus for Gene Transfer."

According to the authors' abstract of an article published in American Journal of Physiology - Heart and Circulatory Physiology, "Gene transfer to the heart has been accomplished with intravascular administration of adenoviral vectors. We hypothesized that administration of adenoviral vectors into the pericardial sac, by increasing the duration of exposure to the adenovirus, would result in gene expression in the pericardium and perhaps myocardium and therefore might provide an alternative method to intravascular administration for gene transfer. We injected a replication-deficient adenovirus (average 1x10¹² particles/ml in 3% sucrose; 1x10¹⁰ plaque forming...

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