Immunotherapy (HIV)
"The Use of Anti-TAT Vector for Adoptive Immunotherapy of AIDS."
Published in Gene Therapy Weekly, March 24th, 1997
According to an abstract submitted by the authors to the Ninth Symposium on HIV Infection entitled From Virology ... To Therapy, held March 6-8, 1997, in Toulon, France, "Objective: HIV infection leads to gradual depletion of CD4+ T helper cells. This leads to fatal opportunistic infections. Therefore reconstitution of the immune system with antigen specific CD4+ T cells will enable the HIV-1 patients to withstand the opportunistic infections. Method: Here we demonstrate that PBMCs taken from healthy individuals, HIV-1 negative donors, were transduced with a retroviral vector coding for an anti-tat antisense sequence. After transduction and...
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Source: Gene Therapy Weekly (1997-03-24)
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