Published in Gene Therapy Weekly, March 24th, 1997
A live attenuated SIV vaccine is the only HIV vaccine prototype to show complete protection in primates. But most observers worry that a live HIV vaccine would be too risky for human use: indeed, baby monkeys given oral doses of the SIV vaccine developed AIDS.
Britta Wahren of the Karolinska Institute, Stockholm, Sweden, and colleagues suggested that plasmids containing the HIV-1 nef, rev, and tat regulatory genes; a gene encoding the p24 structural protein; and a gene encoding the...
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