AIDS Therapies

Researchers Seek AIDS Cell Blocker

Published in Gene Therapy Weekly, April 21st, 1997

Researchers say they have found a way to genetically prevent the formation of a key protein that allows HIV to infect some cells, offering promise for a radically new treatment.

Recent studies have shown that HIV must link with specific proteins on the surface of cells before it can infect the cell. These surface proteins are called receptors.

One of the receptors, CD4, has long been known. Studies in 1996 showed that the virus must also link with one of two other cell receptors, CCR5 or CXCR4.

Generally, the virus uses the CCR5 receptor to invade cells early in the infection. After the virus mutates, it also uses CXCR4.

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Source: Gene Therapy Weekly (1997-04-21)

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