Immunology (HCV)

Humoral Immune Selection Critical in HCV HVR1 Variation

Published in Gene Therapy Weekly, April 28th, 1997

Humoral immune selection appears to be the main force of sequence variation in the hepatitis C virus hypervariable region 1.

Researcher Jacob Odeberg and colleagues suggest, however, that other selection mechanisms may contribute to modulation of the composition of the viral population ("Variation of HCV Hypervariable Region 1 in Immunocompromised Patients," Journal of Infectious Diseases, April 1997;175:938-943).

Hepatitis C virus (HCV) is the major causative agent of non-A, non-B posttransfusion hepatitis and has a positive single stranded RNA of approximately 9.4 kb with a quasispecies nature.

"An isolate of hepatitis C is most...

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Source: Gene Therapy Weekly (1997-04-28)

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