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Antiviral Vaccines

Detoxified Toxin CTL Vaccine Protects Against Virus

Published in Gene Therapy Weekly, May 5th, 1997

A detoxified bacterial toxin can pierce a cell and inject it with an epitope that can elicit antiviral cytotoxic lymphocytes (CTL).

The technique could be used to induce immune responses against a number of viral pathogens, including HIV.

In a dramatic demonstration, French researchers have shown that this approach to vaccination can protect mice against a virus that killed unvaccinated animals.

"To our knowledge, this study represents the first demonstration that a bacterial toxin carrying a viral CD8+ T-cell epitope can induce protective immunity against a lethal virus infection in mice," wrote Pasteur Institute...

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