Cancer Gene Therapy
"Effect of Canarypox Virus (ALVAC)-Mediated Cytokine Expression on Murine Prostate Tumor Growth."
Published in Gene Therapy Weekly, May 12th, 1997
According to the authors' abstract of an article published in Journal of the National Cancer Institute, "Background: Canarypox virus, ALVAC, does not replicate in infected mammalian cells and has potential as a vector for gene therapy in the treatment of cancer. Purpose: Recombinant viruses carrying DNA sequences encoding interleukin 2 (ALVAC-IL-2), interferon gamma (ALVAC-IFN gamma), tumor necrosis factor-alpha (ALVAC-TNF-alpha), or the co-stimulatory molecule B7-1 (ALVAC-B7-1) were investigated as agents for the treatment of a newly defined mouse prostate tumor model. Methods: RM-1 mouse prostate cancer cells, which are syngeneic (i.e., same genetic...
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Source: Gene Therapy Weekly (1997-05-12)
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