Antisense Technology
"Effects of Oligodeoxynucleotides on the Physicochemical Characteristics and Cellular Uptake of Liposomes."
Published in Gene Therapy Weekly, May 26th, 1997
According to the authors' abstract of an article published in Journal of Pharmaceutical Sciences, "We studied the effects of a phosphodiester oligodeoxynucleotide (ODN), which is antisense to the site in the neighborhood of the AUG initiation codon of the mouse tumor necrosis factor alpha gene (TNF-alpha), on the physicochemical characteristics and the cellular association of three types of liposomes with different surface charges. The physicochemical characteristics of the liposomes changed after adding ODN. When the ODN/lipid molar ratio was similar to 0.15 in cationic (TMAG) liposomes [consisting of N-(alpha-trimethylammonioacetyl)didodecyl-D-glutamate chloride (TMAG),...
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Source: Gene Therapy Weekly (1997-05-26)
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