AIDS Therapies

Ability To Synthesize Novel Hypusine Reagent Reported

Published in Gene Therapy Weekly, June 2nd, 1997

SunPharm Corporation, Jacksonville, Florida announced the publication of a paper in the May 16, 1997, issue of The Journal of Organic Chemistry that describes the synthesis of a peptide containing an unusual amino acid called hypusine.

Hypusine normally is found in a protein, eIF5A, that not only may be important in cellular protein synthesis, but also is thought to play a key role in the replication of HIV.

Hypusine is produced by cells through the modification of a single lysine residue in only one cellular protein, eIF5A. During HIV infection, viral protein synthesis has been shown to require interaction of eIF5A with the viral gene product Rev. ...

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Source: Gene Therapy Weekly (1997-06-02)

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