Conference Coverage (AACR)

Adoptive Immunotherapy of Cancer Examined in Murine Model

Published in Gene Therapy Weekly, June 9th, 1997

T lymphocytes from tumor-draining lymph nodes (TDLN), when activated and expanded with anti-CD3 and interleukin-2 (IL-2), exhibited an antitumor effect in a murine model.

Lymph nodes (LN) draining from a progressively growing tumor contain specifically sensitized T lymphocytes. Harvesting these lymphocytes, and then activating and expanding them in vitro with anti-CD3 and IL-2 before injecting them into sublethally irradiated tumor-bearing mice yields an adoptive immunotherapeutic effect.

S. Saffold, representing colleagues from the Cleveland Clinic Foundation, Cleveland, Ohio, presented research at the American Association for Cancer Research...

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Source: Gene Therapy Weekly (1997-06-09)

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