Cancer Gene Therapy
"Phase I Study of Immunotherapy of Hepatic Metastases of Colorectal Carcinoma by Direct Gene Transfer of an Allogeneic Histocompatibility Antigen, HLA-B7."
Published in Gene Therapy Weekly, June 23rd, 1997
According to the authors' abstract of an article published in Gene Therapy, "We have completed a Phase I study to test feasibility and toxicity of immunotherapy of hepatic metastases from colorectal carcinoma by direct gene transfer of HLA-B7, a MHC class I gene. Eligible patients were HLA-B7 negative, immunocompetent by PHA lymphocyte stimulation and had least two measurable hepatic lesions on CT scan for measurement of response of the injected lesion, as well as evaluation of possible distant response. Under ultrasonographic guidance the hepatic lesions were injected with Allovectin-7, a liposomal vector containing the combination the HLA-B7 gene with beta(2)-microglobulin formulated...
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Source: Gene Therapy Weekly (1997-06-23)
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