Heart Disease

Adenovirus Vector Brings Cardiovascular Gene Therapy Closer

Published in Gene Therapy Weekly, June 23rd, 1997

Johns Hopkins University cardiologists have developed a technique for efficiently delivering genes to virtually all the cells in the heart, moving prospects for gene therapy for heart diseases over an imposing barrier.

Using a disabled version of a common virus, the adenovirus, as a carrier, Hopkins researchers "infected" nearly 100 percent of the muscle cells of a rabbit heart with a new gene.

"Our novel delivery system is the first to demonstrate virtually complete transduction of an intact heart and could be adapted to achieve widespread gene transfer in human hearts," said John Lawrence, M.D., assistant professor of cardiology and principal...

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Source: Gene Therapy Weekly (1997-06-23)

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