AIDS Vaccines

Attenuated HIV Still Pathogenic in Mouse Model

Published in Gene Therapy Weekly, June 30th, 1997

Attenuation of HIV-1 by deletion of its nef gene retards but does not prevent CD4⁺ T-cell loss in a mouse model of HIV infection.

By far, the most effective AIDS vaccine prototype is a live simian immunodeficiency virus (SIV) vaccine attenuated by deletions in the nef, vpr, and LTR genes. The new findings may slow the growing support for human tests of a similarly attenuated live HIV vaccine.

"The importance of nef ... seems to be less than that implied by the finding of long-term survivors with spontaneous nef deletions or the absence of simian AIDS in monkeys infected with nef-deficient...

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Source: Gene Therapy Weekly (1997-06-30)

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