Published in Gene Therapy Weekly, July 21st, 1997
Although highly efficient at transferring foreign genes to the liver, as well as to quiescent cells, recombinant adenoviruses (Ads) have a limited duration of gene expression due to both humoral and cellular immune responses by the host against the vector. This antiviral immune response also prevents re-administration of the vector if additional treatment is necessary.
Y. Ilan and colleagues from the Albert Einstein College of Medicine, New...
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