Therapy (HBV)

Destruxin B May Be Useful Agent for Hepatitis B

Published in Gene Therapy Weekly, July 21st, 1997

A compound found in a plant pathogen may have clinical significance for the treatment of hepatitis B virus, according to a report from Taiwan.

Researcher Hua-Chien Chen and colleagues showed that destruxin B, a cyclodepsipeptide, showed a strong suppressive effect on hepatitis B surface antigen (HBsAg) gene expression in human hepatoma cells.

Destruxin B originally was identified from the fungal plant pathogen, Alternaria brassicae. More than 20 structurally related destruxins have been isolated which present a variety of biological activities. For example, destruxin E has been shown to disturb macromolecular syntheses and to have antiviral...

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Source: Gene Therapy Weekly (1997-07-21)

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