Published in Gene Therapy Weekly, July 21st, 1997
Researcher Hua-Chien Chen and colleagues showed that destruxin B, a cyclodepsipeptide, showed a strong suppressive effect on hepatitis B surface antigen (HBsAg) gene expression in human hepatoma cells.
Destruxin B originally was identified from the fungal plant pathogen, Alternaria brassicae. More than 20 structurally related destruxins have been isolated which present a variety of biological activities. For example, destruxin E has been shown to disturb macromolecular syntheses and to have antiviral...
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