Published in Gene Therapy Weekly, July 28th, 1997
PDGF is recognized as a competence factor for fibroblast proliferation. It has not been determined, however, whether this factor actually plays a critical role in the process of pulmonary fibrosis in vivo.
As a first step in determining whether antisense therapy targeting PDGF might reduce the effects of human pulmonary fibrosis, Ken Ohta and colleagues from the Teikyo University School of Medicine, Japan, investigated a murine model of pulmonary fibrosis ("Suppressive Effect of Antisense DNA of Platelet-Derived...
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