Antisense Therapy

Platelet-Derived Growth Factor Suppresses Silica-Induced Pulmonary Fibrosis

Published in Gene Therapy Weekly, July 28th, 1997

Antisense DNA of platelet-derived growth factor (PDGF) has a suppressive effect on the development of pulmonary fibrosis in a murine model.

PDGF is recognized as a competence factor for fibroblast proliferation. It has not been determined, however, whether this factor actually plays a critical role in the process of pulmonary fibrosis in vivo.

As a first step in determining whether antisense therapy targeting PDGF might reduce the effects of human pulmonary fibrosis, Ken Ohta and colleagues from the Teikyo University School of Medicine, Japan, investigated a murine model of pulmonary fibrosis ("Suppressive Effect of Antisense DNA of Platelet-Derived...

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Source: Gene Therapy Weekly (1997-07-28)

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