Published in Gene Therapy Weekly, August 4th, 1997
The findings - from studies of mice infected with the immunosuppressive, leukemia-inducing Friend retrovirus (FV) - are directly relevant to the search for AIDS vaccines and immunotherapies, argue Kim J. Hasenkrug and Bruce Chesebro of the National Institute of Allergy and Infectious Diseases.
"Resolution of retroviral infections may require more complex immunological responses than have been found for most other viruses," Hasenkrug and Chesebro suggested. "Numerous experiments using both genetic and immunological approaches demonstrate that immune resistance to FV...
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