Autoimmune Disease
Tolerance Induced by Eating Plants Expressing Autoantigen
Published in Gene Therapy Weekly, August 4th, 1997
A Canadian research team has successfully induced tolerance to an autoantigen in mice by feeding them transgenic plants expressing the antigen.
"We show that a GAD [glutamic acid decarboxylase]-expressing transgenic plant, given as a dietary supplement, inhibits the development of diabetes in the non-obese diabetic (NOD) mouse," reported S.-W. Ma of the University of Western Ontario, London, Ontario, Canada, and colleagues ("Transgenic Plants Expressing Autoantigens Fed To Mice To Induce Oral Immune Tolerance," Nature Med, 1997;3(7):793-6).
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Source: Gene Therapy Weekly (1997-08-04)
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