"Inhibition of in vivo Tumorigenicity and Invasiveness of a Human Glioblastoma Cell Line Transfected with Antisense uPAR Vectors."

According to the authors' abstract of an article published in Clinical & Experimental Metastasis, "Our previous studies showed that glioblastomas express increased urokinase-type plasminogen activator receptors (uPARs) in comparison to low-grade gliomas (Yamamoto et al., Cancer Res., 54, 5016-5020, 1994). To explore whether downregulation of uPAR inhibits tumor formation and invasiveness, a human globlastoma cell line was transfected with a cDNA construct corresponding to 300 bp of the human uPAR's 5' end in an antisense orientation, resulting in a reduced number of uPA receptors. Co-culture studies with tumor spheroids and fetal rat brain aggregates showed that antisense SNB19-AS1 cells...

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