Cancer Gene Therapy
"Antitumor Efficacy of Adenocarcinoma Cells Engineered to Produce Interleukin 12 (IL-12) or Other Cytokines Compared with Exogenous IL-12."
Published in Gene Therapy Weekly, September 8th, 1997
According to the authors' abstract of an article published in Journal of the National Cancer Institute, "Background: Numerous animal model studies have examined the ability of genetically engineered tumor cells to release cytokines and to elicit an immune memory against the parental tumor. Often, only a single cytokine is studied, and few comparative studies have been conducted. Purpose: We evaluated the antitumor efficacy of adenocarcinoma cells engineered to release interleukin (IL)-12 in a mouse model system. The efficacy of this cytokine was compared with that of other cytokines released by engineered adenocarcinoma cells and that of exogenous IL-12 administered...
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Source: Gene Therapy Weekly (1997-09-08)
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