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Cancer Genetics

New Gene Hints at Family Behind Previously Singular Tumor Suppressor

Published in Gene Therapy Weekly, September 8th, 1997

The famous p53, considered the single most important tumor suppressor gene, is single no more.

Researchers at Harvard Medical School, working in close collaboration with French scientists, have discovered a novel gene that closely resembles p53, a critical factor in tumor development that is mutated in 60 percent of all human cancers. The new gene, called p73, is deleted in at least one type of cancer and resides in an area of the genome that researchers worldwide have for years scoured for suspected tumor suppressor genes.

The researchers published their discovery and an initial analysis of p73 in the August 22,...

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