Transplantation

CTLA4-Ig Gene Transfer Prolongs Adenovirus-Mediated Gene Expression

Published in Gene Therapy Weekly, September 15th, 1997

Transfer of the gene for CTLA4-Ig abrogates the host humoral immune response against the adenoviral vector and prolongs adenoviral-mediated gene expression in a rat model.

The liver is a good target for adenoviral-mediated gene transfer. Results of several liver-targeted adenovirus transfection studies in rodents have demonstrated that gene transfer to the liver is highest at about seven days and has generally diminished by 30 days due to immunological responses against the vector by the host.

The use of immunosuppressive drugs, immunosuppressive cytokines, and CTLA4-Ig have been shown to suppress the anti-vector immunological response and prolong...

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Source: Gene Therapy Weekly (1997-09-15)

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