Published in Gene Therapy Weekly, September 15th, 1997
The liver is a good target for adenoviral-mediated gene transfer. Results of several liver-targeted adenovirus transfection studies in rodents have demonstrated that gene transfer to the liver is highest at about seven days and has generally diminished by 30 days due to immunological responses against the vector by the host.
The use of immunosuppressive drugs, immunosuppressive cytokines, and CTLA4-Ig have been shown to suppress the anti-vector immunological response and prolong...
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