Published in Gene Therapy Weekly, September 15th, 1997
Intracellular immunization against HIV - treatment of infection by genetically engineering antimicrobial resistance into a person's cells - is already being tested in preliminary clinical trials. But a major problem with the technique has been suboptimal expression of the antiviral genes.
Now University of Michigan researchers Udaykumar Ranga, Gary J. Nabel, and colleagues report development of an improved gene-delivery vector that includes CD4 specific regulatory elements and viral regulatory regions.
"This vector was 100- to 1,000-fold more active...
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