Cancer Gene Therapy
IL-1(beta) Gene Transfer to Melanoma Cells Regulates Tumor Growth
Published in Gene Therapy Weekly, September 22nd, 1997
IL-1 is a cytokine with different properties from most other cytokines: it lacks a signal sequence. This means that it remains in its immature proform within cells. The release of IL-1 has been shown to be restricted predominantly to activated monocytes and macrophages, and is associated with apoptosis of the producer cell. IL-1(beta) has important immunological and pro-inflammatory properties. It activates endothelial cells; increases the expression of adhesion molecules in various cell types;...
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Source: Gene Therapy Weekly (1997-09-22)
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