Vectors
"Adeno-Associated Virus as a Gene Delivery System."
Published in Gene Therapy Weekly, September 29th, 1997
According to the author's abstract of an article published in Advanced Drug Delivery Reviews, "Adeno-associated virus (AAV) has several characteristics which make it extremely attractive as a gene transfer vector: (1) no known pathogenicity; (2) high efficiency and the ability to remain latent, (3) a minimal number of antigens ensuring minimal immunogenicity; (4) the ability to transduce post-mitotic cells; (5) possible advantages of site-specific integration; and (6) a broad host and cell range. The human isolate, AAV-2, is the best studied and has been the focus for gene delivery experiments. This review will discuss recent in vivo experiments demonstrating the utility of AAV in...
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Source: Gene Therapy Weekly (1997-09-29)
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