Coinfection (HCV/HBV)

Silent Hepatitis B Mutant May Promote HCV Replication

Published in Gene Therapy Weekly, October 20th, 1997

Hepatitis C virus frequently occurs with coinfection by the silent hepatitis B virus mutant, according to a report from Japan.

The silent hepatitis B virus (HBV) mutant appears to promote the replication of hepatitis C virus (HCV) in the liver, researcher Toshikazu Uchida and colleagues noted ("Hepatitis C Virus is Frequently Coinfected with Serum Marker-Negative Hepatitis B Virus: Probable Replication Promotion of the Former by the Latter as Demonstrated by In Vitro Cotransfection," Journal of Medical Virology 1997;52:399-405).

The complete nucleotide (nt) sequence of serum marker-negative (silent) HBV recovered from patients with acute hepatitis...

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Source: Gene Therapy Weekly (1997-10-20)

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