Cancer Vaccines
Certain Oligodeoxynucleotides Show Promise as Vaccine Adjuvants
Published in Gene Therapy Weekly, October 27th, 1997
Research has shown that immunostimulatory ODN containing the CpG motif (CpG ODN) can induce production of a wide variety of cytokines as well as activating B cells, monocytes, dendritic cells, and natural killer (NK) cells.
Expanding on previous research which found that CpG ODN could enhance antibody-dependent cellular cytotoxicity and improve the in vivo efficacy of monoclonal antibody therapy in a syngeneic murine lymphoma model (Blood 1997;89:2994-98), George J. Weiner and colleagues from the University of Iowa and...
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Source: Gene Therapy Weekly (1997-10-27)
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