Vector Development

Noninfectious VLPs Become Infectious by Addition of Lipofection Reagents

Published in Gene Therapy Weekly, October 27th, 1997

Noninfectious virus-like particles (VLP) produced by Moloney murine leukemia virus (MoMLV)-based retrovirus packaging cells deficient in viral envelope can become infectious in the presence of lipofection reagents.

"Pseudotyped" virus particles can be produced when the envelope component of one retrovirus is substituted by the envelope of another virus. The new pseudotyped virus particles then exhibit a cell tropism specified by the new env component (D.G. Miller et al., PNAS 1994;91:78-82; and others). This has been extended further to the development of targetable retrovirus vectors through the insertion of tissue-specific ligands into the env molecule...

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Source: Gene Therapy Weekly (1997-10-27)

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