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Cancer Gene Therapy

Yale Basic Research Provides Impetus for Potential Treatment

Published in Gene Therapy Weekly, October 27th, 1997

A genetically engineered strain of the bacterium Salmonella potentially may target cancerous tumors, amplify within tumors, and inhibit tumor growth, according to new research reported by Yale University School of Medicine, New Haven, Connecticut, scientists.

The Yale concept, reported in the October 15, 1997, issue of the journal Cancer Research, and licensed to Vion Pharmaceuticals Inc. in New Haven, Connecticut, involves the use of engineered strains of the common Salmonella bacterium, the same bacterium that, in its unaltered or wild type form, can cause food poisoning and septic shock. The altered Salmonella, stripped of its pathogenicity, is...

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