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Cancer Gene Therapy (Delivery)

HUVEC Used as a Cellular Vehicle for Gene Therapy

Published in Gene Therapy Weekly, November 3rd, 1997

HSVtk/GCV suicide gene therapy has a new cellular vehicle for gene product delivery: human umbilical endothelial vein cells (HUVEC) have been successfully used to deliver toxic gene products to tumor cells in vivo.

Researchers C. Rancourt and colleagues from the University of Alabama, Birmingham, Alabama, examined the feasibility of using HUVEC as vehicles for delivery toxin gene products to tumor sites. They presented in vitro and in vivo results at the 3rd European Conference on Gene Therapy of Cancer, held September 11-13, 1997, in Berlin, Germany ("Human Endothelial Cells as Cellular Vehicles for Ovarian Cancer Gene Therapy").

After initially...

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